IBM PET project tackles human fungal infections

PRW

Published: December 9, 2013 3:37 pm ET
Updated: December 9, 2013 3:39 pm ET

Related to this story

Topics Medical

Researchers from IBM and Singapore’s Institute of Bioengineering and Nanotechnology (IBN) have converted PET into a non-toxic and biocompatible drug delivery system designed to attack fungal infections.

The new antifungal agents self-assemble in the bloodstream through a hydrogen-bonding process to form nanofibers, which attach to fungal membranes using electrostatic attraction, according to a peer-reviewed paper published by Nature Comm. These then break through the membrane wall of the fungal cell, destroying its infective content.

According to Dr. Yi Yan Yang, the group leader at IBN, said: “The ability of these molecules to self-assemble into nanofibers is important because unlike discrete molecules, fibers increase the local concentration of cationic charges and compound mass. This facilitates the targeting of the fungal membrane and its subsequent lysis, enabling the fungi to be destroyed at low concentrations.”

Over a billion people are affected by fungal infections every year, ranging in severity from topical skin conditions like athlete’s foot to life-threatening fungal blood infections, claimed the research team. The infection is more likely to occur when the body’s immune system is compromised due to an illness such as HIV, cancer or when receiving antibiotic treatment.


Comments

IBM PET project tackles human fungal infections

PRW

Published: December 9, 2013 3:37 pm ET
Updated: December 9, 2013 3:39 pm ET

Post Your Comments


Back to story


More stories

Some medical devices could get faster approval with new FDA rules

April 22, 2014 7:41 pm ET

The U.S. Food and Drug Administration is proposing an expedited approval for medical devices for devices aimed at the diagnosis or treatment of...    More

Image

Two Ohio groups team up to accelerate development of future medical devices

April 22, 2014 9:55 am ET

The Austen BioInnovation Institute in Akron and Cleveland-based design specialists Nottingham Spirk announced a strategic partnership that the two...    More

MGS buying N.Y. medical molding plant from Hospira

April 17, 2014 10:19 pm ET

MGS Manufacturing Group is purchasing the Buffalo, N.Y., injection molding facility and related product line of Hospira Inc., effective July 1. Terms ...    More

No action yet, but opposition still brewing to medical device tax

April 11, 2014 1:29 pm ET

Indiana politicians are stepping up their game in attempts to get the much-maligned medical device tax repealed.    More

Market Reports

Market Data Book - Rankings & Lists

A one-stop download of Plastic News' exclusive annual lists and processor rankings containing essential data including sales, employees, end markets, materials and more.
EXCLUSIVE EXCEL FEATURE: full mailing address details for available plant locations.

Learn more

Thermoformed Packaging 2014 Market Review & Outlook North America

This in-depth report provides analysis and discussions of economic and political conditions, market trends, legislative/regulatory activity impacting supply and demand, business opportunities and threats, materials pricing, manufacturing technology, as well as strategies being implemented by thermoformed packaging companies. In addition, there are reviews of 25 leading thermoformers in the packaging segment, assessing their growth initiatives and performance metrics over 10 years.

Learn more

Mold Making and Tooling Review and Outlook 2014 North America

This report provides in-depth analysis of the mold and toolmaking market for North America, including discussions of trends, opportunities, threats, the latest developments in production and labor and equipment trends impacting moldmakers.

Learn more

Upcoming Plastics News Events

May 6, 2014 - May 8, 2014Plastics in Medical Devices 2014

May 12, 2014 - May 12, 2014Plastics News Brazil Pharma Summit

September 10, 2014 - September 12, 2014Plastics Caps & Closures 2014

February 3, 2015 - February 7, 2015Plastics News Executive Forum 2015

More Events