Particle Sciences Inc. has expanded its development and pilot production capabilities with the addition of a Leistritz ZSE 18mm twin-screw compounding extruder to its Class 10,000 clean room.
The Bethlehem, Pa.-based company develops thermoplastic-based combination products referred to as drug-eluting devices.
Particle Sciences will use the line to compound materials used in the manufacture of implantable devices that slowly release drugs to treat or prevent diseases.
The machine will increase our throughput, allowing production at higher volumes with higher quality, said Andrew Loxley, new technologies director.
Particle Sciences is developing drug-eluting intravaginal rings by mixing microbicides into polymers such as ethylene vinyl acetate. The compounded material is then injection molded into the rings. Particle Sciences also helps other companies develop devices, such as sub-coetaneous implants that are designed to be placed under the skin, where the devices release wound-healing drugs, contraceptives and analgesics.
The new line can be used to compound drugs with excipients other than ethylene-vinyl acetate to make different solid dosage forms, Loxley said.
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