An industry-funded study has found no evidence of any adverse impact on brain or neurological development in rats whose mothers were exposed to dietary doses of bisphenol A during their pregnancy.
The extensive evaluations in this study clearly showed that there were no functional, sensory or cognitive deficits resulting from BPA exposure during neurodevelopment, nor was there any evidence of effects on motor activity during the development of an organism from the fertilized egg to mature form, researchers said in a study published online Feb. 17 in Toxicological Sciences, the scientific journal of the Society of Toxicology.
SOT is a professional organization of scientists from academic institutions, government and industry who practice toxicology.
The research was funded by the Polycarbonate/BPA Global Group of the American Chemistry Council in Arlington, Va., and conducted by Wil Research Laboratories LLC in Ashland, Ohio. Wil is a contract research organization for the pharmaceutical, biotechnology, chemical, agricultural, veterinary, and food and consumer products industries.
In the study, pregnant rodents were given both low and high doses of BPA in their milk and food, based on guidelines for the study of developmental neurotoxicity from both the U.S. Environmental Protection Agency and the international Organisation for Economic Co-operation and Development, based in Paris.
A previous low-dose study by EPA had also found that low doses of BPA did not affect brain reproduction or development.
However, a number of other laboratory studies previously have linked BPA used to make PC and epoxy resins to birth defects, low birth weight, cancer, early puberty and other health problems in rats.
Still, nearly a dozen safety agencies around the world have said BPA is safe for food-contact uses.
In mid-January, the Food and Drug Administration reversed its long-held stance that BPA is safe for food-contact applications. Regulators said they were particularly concerned about BPA's effect on the development of fetuses, infants and young children. However, the FDA did not ban BPA or require manufacturers to label products that contain BPA, saying that there is not enough information for such a requirement.
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